Norio Takagi Selected Research

Leukemia

1/2023	Cytotoxic Effects of Darinaparsin, a Novel Organic Arsenical, against Human Leukemia Cells.
1/2021	Cytotoxic Effects of Arsenite in Combination With Gamabufotalin Against Human Glioblastoma Cell Lines.
10/2018	Enhanced cytotoxic effects of arsenite in combination with anthocyanidin compound, delphinidin, against a human leukemia cell line, HL-60.
1/2016	Multidrug resistance-associated protein 4 is a determinant of arsenite resistance.
12/2013	Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines.

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Norio Takagi Research Topics

Disease

37	Brain Ischemia (Cerebral Ischemia) 01/2022 - 01/2002
26	Ischemia 02/2022 - 01/2003
16	Embolism (Embolus) 05/2013 - 01/2002
12	Neoplasms (Cancer) 01/2023 - 01/2002
11	Breast Neoplasms (Breast Cancer) 01/2021 - 08/2017
7	Necrosis 01/2023 - 07/2003
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 12/2005
5	Leukemia 01/2023 - 12/2013
5	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 09/2016
5	Wounds and Injuries (Trauma) 01/2021 - 03/2006
5	Stroke (Strokes) 03/2020 - 10/2002
5	Acute Promyelocytic Leukemia 01/2018 - 03/2014
5	Brain Injuries (Brain Injury) 05/2013 - 02/2004
4	Infarction (Infarctions) 01/2018 - 02/2003
4	Myocardial Infarction 05/2014 - 01/2013
4	Cerebral Infarction 03/2011 - 06/2008
3	Neuroblastoma 08/2021 - 01/2021
3	Triple Negative Breast Neoplasms 01/2021 - 01/2018
3	Neoplasm Metastasis (Metastasis) 12/2019 - 01/2019
2	Ischemic Stroke 01/2024 - 08/2021
2	Body Weight (Weight, Body) 01/2021 - 03/2020
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2020 - 06/2008
2	Inflammation (Inflammations) 10/2019 - 08/2019
2	Lymphoma (Lymphomas) 01/2019 - 01/2002
2	Hematologic Neoplasms (Hematological Malignancy) 06/2018 - 12/2013
2	Heart Failure 05/2014 - 01/2013
2	Mitochondrial Diseases (Mitochondrial Disease) 05/2014 - 01/2013
2	Transient Ischemic Attack 03/2011 - 05/2004
2	Hypertrophy 02/2008 - 01/2004
1	Smith-Magenis Syndrome 02/2024
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/2024
1	Frontotemporal Dementia (Semantic Dementia) 02/2024
1	Frontotemporal Dementia With Motor Neuron Disease 02/2024
1	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 01/2023

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 02/2024 - 01/2004
10	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2022 - 01/2003
10	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 10/2009 - 07/2004
9	arseniteIBA 01/2021 - 07/2015
8	ArsenicIBA 01/2021 - 01/2016
7	N-Methylaspartate (NMDA)IBA 01/2022 - 05/2004
7	Tyrosine (L-Tyrosine)FDA Link 11/2012 - 01/2003
6	arsenic disulfide (realgar)IBA 01/2020 - 01/2018
5	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/2017 - 05/2002
5	nefiracetamIBA 01/2005 - 10/2002
4	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 10/2009
4	Glutamic Acid (Glutamate)FDA Link 01/2022 - 10/2010
4	gamabufotalinIBA 01/2021 - 09/2016
4	tetrandrineIBA 01/2020 - 08/2017
4	src-Family KinasesIBA 01/2016 - 06/2008
4	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 10/2010 - 02/2002
4	OccludinIBA 08/2010 - 01/2006
4	Adenylyl Cyclases (Adenylyl Cyclase)IBA 03/2003 - 01/2002
3	ProgranulinsIBA 02/2022 - 10/2019
3	Ionotropic Glutamate ReceptorsIBA 01/2022 - 12/2005
3	bufadienolideIBA 01/2021 - 09/2016
3	p38 Mitogen-Activated Protein KinasesIBA 01/2021 - 08/2014
3	arenobufaginIBA 01/2021 - 09/2016
3	Nerve Growth Factors (Neurotrophins)IBA 03/2020 - 03/2008
3	AlkaloidsIBA 01/2020 - 08/2017
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 03/2019 - 01/2003
3	NADPH Oxidases (NAD(P)H oxidase)IBA 03/2011 - 10/2006
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 03/2006 - 02/2002
3	Calmodulin (Calcium-Dependent Activator Protein)IBA 04/2003 - 01/2002
2	sivelestatIBA 02/2022 - 01/2021
2	Secretory Proteinase Inhibitory ProteinsIBA 02/2022 - 01/2021
2	Estrogen ReceptorsIBA 01/2021 - 01/2018
2	Oxygen (Dioxygen)IBA 01/2021 - 10/2009
2	hellebrigeninIBA 01/2021 - 12/2018
2	Pancreatic Elastase (Elastase)IBA 01/2021 - 10/2019
2	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2021 - 10/2019
2	WortmanninIBA 01/2021 - 01/2020
2	EnzymesIBA 01/2021 - 01/2016
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2019 - 03/2013
2	FurinIBA 01/2019 - 01/2018
2	delphinidinIBA 10/2018 - 07/2015
2	Neuroprotective AgentsIBA 01/2018 - 01/2015
2	Insulin (Novolin)FDA Link 12/2017 - 01/2004
2	Arsenic Trioxide (Trisenox)FDA Link 01/2016 - 01/2016
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2016 - 03/2014
2	Small Heat-Shock ProteinsIBA 05/2014 - 01/2013
2	HSP72 Heat-Shock ProteinsIBA 01/2013 - 01/2013
2	metabotropic glutamate receptor type 1IBA 09/2010 - 06/2008
2	Dihydrotachysterol (AT 10)IBA 05/2008 - 01/2003
2	tanshinone VIIBA 02/2008 - 01/2004
2	DiterpenesIBA 02/2008 - 01/2004
2	Apoptosis Inducing FactorIBA 11/2007 - 11/2006
2	Bromodeoxyuridine (BrdU)IBA 02/2005 - 05/2004
2	acetamideIBA 01/2005 - 10/2002
2	salicylhydroxamic acid (SHAM)IBA 05/2004 - 01/2003
2	Cholinergic Agents (Cholinergics)IBA 10/2002 - 02/2002
2	OF 900IBA 05/2002 - 01/2002
2	imidodiphosphonic acidIBA 05/2002 - 01/2002
1	NucleotidesIBA 02/2024
1	C9orf72 ProteinIBA 02/2024

Therapy/Procedure

24	Microspheres (Microsphere) 03/2020 - 01/2002
5	Therapeutics 03/2020 - 11/2006
3	Ligation 05/2014 - 01/2013
3	Intravenous Injections 05/2013 - 01/2011
3	Treatment Delay 02/2003 - 10/2002
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 03/2020 - 03/2020